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secE [2019-06-06 12:24:10]
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secE [2019-06-06 12:24:10]

preprotein translocase subunit
locus
BSU01000
pI
10.47
mw
6.79 kDa
protein length
59 aa Sequence Blast
gene length
180 bp Sequence Blast
function
protein secretion
product
preprotein translocase subunit
essential
yes
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    117,532 117,711

    Phenotypes of a mutant

  • essential [Pubmed|12682299] [Pubmed|7968510]

    • The protein

    Protein family

  • secE/SEC61-gamma family (according to Swiss-Prot)

    • [SW|Domains]

  • transmembrane protein with a single TM domain

    • Structure

  • [PDB|3DL8] (structure of the ([protein|5350DC618130E013757EE667B9AFC5F2EC68EC08|SecY]-[protein|1007EA15FB7AF81A44400287DB68BCC497158ACF|SecE]-[protein|D8851F453E5EF18D36F25834A8CB9C61EAF15E44|SecG])-[protein|AD7CD451B4AE638A719C91780339784A7FF0F248|SecA] complex) [Pubmed|18923516]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Additional information

  • B. subtilis secE complements the secretion phenotype of a cold sensitive E. coli secE mutant.

    • Expression and Regulation

    Operons

    genes
    [gene|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH]-[gene|BBD82B93D5E880AB7093ED53DDB149B0E0B3BAE4|rpmGB]-[gene|1007EA15FB7AF81A44400287DB68BCC497158ACF|secE]
    description
    [Pubmed|22383849]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|1898930], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB]: repression, [Pubmed|7592498], in [regulon|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB regulon]

    • regulation

  • repressed during logrithmic growth ([protein|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB]) [Pubmed|7592498]
    • view in new tab

    References

    Reviews

  • 25212246,27890920

    • Original publications

  • 7968510,18923516,26747607